Upregulation of TACE/ADAM17 after Ischemic Preconditioning is Involved in Brain Tolerance
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چکیده
منابع مشابه
Ischemic preconditioning is capable of inducing mitochondrial tolerance in the rat brain.
BACKGROUND Preconditioning to ischemia is a phenomenon whereby a brief episode of sublethal ischemia and other nonlethal stressors produce protection against a subsequent detrimental ischemic insult. As mitochondrial dysfunction is related to necrotic and apoptotic neuronal death after cerebral ischemia, the authors examined if ischemic preconditioning is capable of inducing mitochondrial toler...
متن کاملBrain tolerance and preconditioning.
In this review article the authors describe a phenomenon of "brain tolerance" which represents transient resistance of brain tissue to a lethal insult established by preconditioning with a mild insult of short duration. Tolerance evoked by brief ischemia resembles transient ischemic attack(s) (TIA) often preceding full-blown ischemic stroke in a clinical setting. A series of recent studies have...
متن کاملIschemic preconditioning in the brain.
physiologic responses to its environment is important for survival. Certain organs respond to sub-lethal exposures to hypoxia or ischemia by a variety of physiologic mechanisms. Some of these mechanisms induce a greater tolerance to a subsequent exposure to hypoxia or ischemia. This phenomenon is described as ischemic or hypoxic preconditioning.1,2 It is nature’s “what doesn’t kill you makes yo...
متن کاملActivation of canonical notch signaling pathway is involved in the ischemic tolerance induced by sevoflurane preconditioning in mice.
BACKGROUND A wealth of evidence has demonstrated that sevoflurane preconditioning induces brain ischemic tolerance, but the mechanism remains poorly understood. This study was designed to investigate the role of canonical Notch signaling in the neuroprotection induced by sevoflurane preconditioning in a mouse model. METHODS C57BL/6 mice were pretreated with 1-h sevoflurane exposure at a dose ...
متن کاملHypoxic Preconditioning-Induced Cerebral Ischemic Tolerance
Background and Purpose—The importance of bioactive lipid signaling under physiological and pathophysiological conditions is progressively becoming recognized. The disparate distribution of sphingosine kinase (SphK) isoform activity in normal and ischemic brain, particularly the large excess of SphK2 in cerebral microvascular endothelial cells, suggests potentially unique celland region-specific...
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ژورنال
عنوان ژورنال: Journal of Cerebral Blood Flow & Metabolism
سال: 2002
ISSN: 0271-678X,1559-7016
DOI: 10.1097/01.wcb.0000033968.83623.d0